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Tadalafil is an annulated 2,5-diketopiperazine. [25] It is also a 1,2,3,4-tetrahydro-β-carboline. Tadalafil can be synthesized starting from (D)-tryptophan methyl ester and piperonal via a Pictet–Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring: [26]
Design date. 1976. The United States two-dollar bill (US$2) is a current denomination of United States currency. A portrait of Thomas Jefferson, the third president of the United States (1801–1809), is featured on the obverse of the note. The reverse features an engraving of John Trumbull 's painting Declaration of Independence ( c. 1818 ).
A "personal computer" version of Windows is considered to be a version that end-users or OEMs can install on personal computers, including desktop computers, laptops, and workstations. The first five versions of Windows– Windows 1.0, Windows 2.0, Windows 2.1, Windows 3.0, and Windows 3.1 –were all based on MS-DOS, and were aimed at both ...
On March 13, 2009, a 67-year-old Ohio woman named Joanne Schneider was sentenced to three years in prison, the minimum allowed, for operating a Ponzi scheme that cost investors an estimated $60 million. [91] On appeal she was sentenced to 10 years. [citation needed]
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For example, Alexion Pharmaceutical, Inc. released Soliris in 2007 with an indication for a rare blood disorder. Treatment with Soliris costs roughly $410,000 per year, and has led to $2.8 billion in total sales in 2016, even with a patient base of only 9,000 people. [82]
Emdeon shares jumped 13.6% the morning after the acquisition. Shares had risen 31% over the year prior to the announcement. [22] In May 2012, the company acquired TC3 Health, a cost containment provider, including payment integrity and out-of-network claims cost management, to U.S. healthcare payers. [23]
The da Vinci Surgical System is a robotic surgical system that uses a minimally invasive surgical approach. The system is manufactured by the company Intuitive Surgical. The system is used for prostatectomies, increasingly for cardiac valve repair and for renal [ 1] and gynecologic surgical procedures. [ 2][ 3] It was used in an estimated ...
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