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Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and works by increasing sugar loss in urine. [2] Empagliflozin was approved for medical use in the United States and in the European Union in 2014. [11] [22] [23] It is on the World Health Organization's List of Essential Medicines. [24]
The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections . [5] [6] The most serious side effects include ketoacidosis (high blood levels of acids called ‘ketoacids’), pancreatitis (inflammation of the pancreas), hypersensitivity (allergic reactions) and hypoglycaemia (low blood sugar levels).
To reduce the risk of developing ketoacidosis (a serious condition where the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medications, recommending they be temporarily stopped before scheduled surgery.
Semaglutide is not a WHO-recommended treatment for diabetes management due to its current high cost, but the agency said it was working on a rapid advice guideline on use of GLP-1 drugs for ...
It was the first oral treatment, in combination with insulin, to treat type 1 diabetes in the UK and EU. Empagliflozin, approved in the United States in August 2014, under the brand name Jardiance by Boehringer Ingelheim. [30] Of the gliflozins, empagliflozin and tofogliflozin have the highest specificity for SGLT2 inhibition. [1]
In the European Union empagliflozin/metformin is indicated in adults aged 18 years and older with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control: [5] in adults inadequately controlled on their maximally tolerated dose of metformin alone; [5]
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Linagliptin is a dipeptidyl peptidase-4 inhibitor [8] that works by increasing the production of insulin and decreasing the production of glucagon by the pancreas. [8] Linagliptin was approved for medical use in the United States, [11] Japan, the European Union, Canada, and Australia in 2011. [8] [12] In 2020, it was the 293rd most commonly ...
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