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Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and works by increasing sugar loss in urine. [ 2] Empagliflozin was approved for medical use in the United States and in the European Union in 2014. [ 11][ 22][ 23] It is on the World Health Organization's List of Essential Medicines. [ 24]
The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections . [5] [6] The most serious side effects include ketoacidosis (high blood levels of acids called ‘ketoacids’), pancreatitis (inflammation of the pancreas), hypersensitivity (allergic reactions) and hypoglycaemia (low blood sugar levels).
SGLT2 inhibitor. SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional units of the kidney ), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa. The foremost metabolic effect of this is to inhibit reabsorption ...
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Altogether, the Congressional Budget Office estimates that the law will save Medicare $98.5 billion over 10 years. Another 30 drugs will be selected for prices to be negotiated in 2027 and 2028.
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