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Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and works by increasing sugar loss in urine. [2] Empagliflozin was approved for medical use in the United States and in the European Union in 2014. [11] [22] [23] It is on the World Health Organization's List of Essential Medicines. [24]
[5] [6] It is taken by mouth. [5] [6] The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections . [5] [6] It was approved for use in the United States in January 2015, [7] [8] for use in the European Union in November 2016, [6] and for use in Australia in December 2016. [2]
[5] It was approved for use in the European Union in May 2015, [5] for use in the United States in August 2015, [6] and for use in Australia in May 2020. [2] In 2020, it was the 238th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [7] [8] It is available as a generic medication. [9]
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SGLT2 inhibitor. SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional units of the kidney ), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa. The foremost metabolic effect of this is to inhibit reabsorption ...
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